Proton Pump Inhibitors and Clopidogrel – Hazardous Drug Interaction or Hazardous Interpretation of Data?
نویسندگان
چکیده
منابع مشابه
Drug interaction between clopidogrel and proton pump inhibitors.
Proton pump inhibitors (PPIs) have been recommended for reducing the risk of gastrointestinal bleeding associated with dual antiplatelet therapy (aspirin plus clopidogrel). However, studies have found decreased efficacy of clopidogrel when concurrently administered with a PPI. To determine the mechanism of and evidence for the potential interaction between clopidogrel and PPIs, along with the c...
متن کاملClopidogrel and proton pump inhibitors: a new drug interaction?
Clopidogrel is a thienopyridine platelet antagonist that irreversibly inhibits the binding of adenosine diphosphate to platelet receptors, ultimately leading to inhibition of platelet aggregation. Clopidogel is a prodrug requiring hepatic bioactivation via cytochrome P450 isozymes (CYP2C19, CYP3A4, CYP3A5) to its pharmacologically active form. Inhibition of cytochrome P450 may interfere with me...
متن کاملInteraction between clopidogrel and proton pump inhibitors.
The drug interaction between proton pump inhibitors and clopidogrel has been the subject of much study in recent years. Contradictory results regarding the effect of proton pump inhibitors on platelet reactivity and on clinical outcome in clopidogrel-treated patients have been reported in literature. Concomitant use of omeprazole and clopidogrel was found to decrease the exposure (AUC) to clopi...
متن کاملProton pump inhibitors and clopidogrel: putting the interaction in perspective.
With this background, the recently postulated drug interaction between proton pump inhibitors (PPIs) and clopidogrel is in a league of its own, spawning a flurry of research and editorializing in a relatively short time, and more is on the way. This attention reflects several factors, including the blockbuster status of the implicated drugs, a theoretically at-risk population in the tens of mil...
متن کاملA population-based study of the drug interaction between proton pump inhibitors and clopidogrel.
BACKGROUND Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active metabolite. The clinical significance of this drug interaction is unknown. METHODS We conducted a population-based nested case-control study among patients aged 66 years or older who commenced clopidogrel between Apr. 1, 2002, and Dec. 31, 2007, following hospital discharge after treatment of acute m...
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ژورنال
عنوان ژورنال: Canadian Journal of Gastroenterology
سال: 2009
ISSN: 0835-7900
DOI: 10.1155/2009/868946